Both collections offer self-assembly kits targeting children and adults.
The Airfix range focuses on the development of flight and automobiles. The Twentieth Century Flight range includes five self-assembly model planes, while the Automotive collection features three cars including the Ford Model T.
The Bitz line, meanwhile, moves the Science Museum into the area of human biology with nine anatomy puzzle kits with up to 46 pieces in each. There are also six space kits in the line-up.
Lucy McCredie, licensing manager for the museum, said: "It is fantastic to have signed two such high quality licensees for the self-assembly kits and puzzles - an area that is very important to us.
"These new ranges will offer individuals a unique opportunity to learn and understand about what they are building, as well as the challenge and satisfaction of producing the finished product."