The Oscar-winning movie has passed the $400 million milestone at international box office.
Marks the second year in a row that Disney has triumphed in the category.
While Shaun the Sheep debuts in third.
Both up for Best Animated Feature, while The LEGO Movie misses out.
The feature will run before all screenings of Big Hero 6 and tells the life story of a cute Boston Terrier through a succession of meals.
The film is based on the Marvel comic book of the same name and will follow the story of Hiro Hamada, a robotic genius.